HOW STRONTIUM89 WORKS

Works at the site of pain

To understand how Strontium89 works, it helps to understand what happens to the bone when bone mets are involved. When bones are working right, new bone is forming while old bone is dissolving. Bone mets can change this natural process by causing more bone formation than normal. This can lead to pain.

Strontium89 is different from other types of pain relief treatment.

It works by delivering a radioactive material to the site of the bone mets. When Strontium89 is injected into the vein, it travels to areas of the bone where cancer is present and gives off radiation that destroys cancer cells. Strontium89 can treat multiple areas of the bone affected by cancer while causing minimal risk of damage to surrounding healthy cells.

Strontium89 may cause bone marrow side effects which can result in lower white blood cell and platelet counts. Learn more about potential side effects.

A look at how Strontium89 works at the site of bone mets

Strontium89 is injected into your vein over the course of 1 to 2 minutes

Strontium89 travels to the areas of bone with bone mets

There, it works by bringing small doses of radiation to the cancer cells

Over time, Strontium89 may relieve the painful bone mets. Many patients feel pain relief within 7 to 20 days. Just one injection can last approximately 3 months.

Strontium89 is not an opioid. It is non-narcotic and non-habit forming.

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Indication and important safety information

INDICATION

Strontium89 (Strontium Chloride Sr-89 Injection, USP) is used for the relief of bone pain in patients with bone metastases. You should only use Strontium89 if you have been diagnosed with metastatic bone cancer.

IMPORTANT SAFETY INFORMATION

Strontium89 may affect bone marrow and may cause white blood cell and platelet counts to be lower than normal. To monitor these effects, your doctor will perform regular blood tests before and after your injection, usually at least every other week until your levels have recovered. This may take up to 6 months. Your doctor will decide if it is safe for you to get a repeat injection, 90 days later, if needed. If you already have seriously decreased bone marrow function, your doctor may decide that you should not receive Strontium89.

Tell your doctor if you are pregnant or planning to become pregnant. Strontium89 may cause harm to your unborn baby and should not be used if you are pregnant or planning to become pregnant. You should not nurse your baby while using Strontium89.

You should not use Strontium89 if you do not have cancer in your bone.

You should not use Strontium89 if you are younger than 18 years old.

You may feel flushed (your skin may get red and warm) right after your injection.

Side effects in clinical studies:

- One patient died from a blood infection caused by a severely low white blood cell count.

- A small number of patients reported a mild and brief increase in bone pain within 36 to 72 hours after injection that was controlled with oral pain medication.

- One patient had chills and fever 12 hours after injection but recovered.

These are not all of the side effects of Strontium89. If you have any questions or concerns about side effects, you should contact your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call (800) FDA-1088.

Please see full Prescribing Information

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Indication and important safety information

INDICATION

Strontium89 (Strontium Chloride Sr-89 Injection, USP) is used for the relief of bone pain in patients with bone metastases. You should only use Strontium89 if you have been diagnosed with metastatic bone cancer.

IMPORTANT SAFETY INFORMATION

Strontium89 may affect bone marrow and may cause white blood cell and platelet counts to be lower than normal. To monitor these effects, your doctor will perform regular blood tests before and after your injection, usually at least every other week until your levels have recovered. This may take up to 6 months. Your doctor will decide if it is safe for you to get a repeat injection, 90 days later, if needed. If you already have seriously decreased bone marrow function, your doctor may decide that you should not receive Strontium89.

Tell your doctor if you are pregnant or planning to become pregnant. Strontium89 may cause harm to your unborn baby and should not be used if you are pregnant or planning to become pregnant. You should not nurse your baby while using Strontium89.

You should not use Strontium89 if you do not have cancer in your bone.

You should not use Strontium89 if you are younger than 18 years old.

You may feel flushed (your skin may get red and warm) right after your injection.

Side effects in clinical studies:

- One patient died from a blood infection caused by a severely low white blood cell count.

- A small number of patients reported a mild and brief increase in bone pain within 36 to 72 hours after injection that was controlled with oral pain medication.

- One patient had chills and fever 12 hours after injection but recovered.

These are not all of the side effects of Strontium89. If you have any questions or concerns about side effects, you should contact your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call (800) FDA-1088.

Please see full Prescribing Information

Please see full Prescribing Information

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Have questions about Strontium89?

We will be happy to assist you. Simply call (855) 226-6344 or email info@qbiomed.com and you will receive a reply within 24 hours. If you would like to report an adverse event, email: SR89MedInfo@QBioMed.com or Call (855) 226-6377

©2021 Q BioMed Inc. All rights reserved. US-SR89WEB_0010 MAR2021

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If you have questions about Strontium89 or would like to report an adverse event,

©2021 Q BioMed Inc. All rights reserved. US-SR89WEB_0010 MAR2021